Ultra-Low Field Nuclear Magnetic Resonance: A New MRI Regime

by Robert Kraus, Michelle Espy, Per Magnelind, Petr Volegov

This book is designed to introduce the reader to the field of NMR/MRI at very low magnetic fields, from milli-Tesla to micro- Tesla, the ultra-low field (ULF) regime. The book is focused on applications to imaging the human brain, and hardware methods primarily based upon pre-polarization methods and SQUID-based detection. The goal of the text is to provide insight and tools for the reader to better understand what applications are best served by ULF NMR/MRI approaches. A discussion of the hardware challenges, such as shielding, operation of SQUID sensors in a dynamic field environment, and pulsed magnetic field generation are presented. One goal of the text is to provide the reader a framework of understanding the approaches to estimation and mitigation of low signal-to-noise and long imaging time, which are the main challenges. Special attention is paid to the combination of MEG and ULF MRI, and the benefits and challenges presented by trying to accomplish both with the same hardware. The book discusses the origin of unique relaxation contrast at ULF, and special considerations for image artifacts and how to correct them (i.e. concomitant gradients, ghost artifacts). A general discussion of MRI, with special consideration to the challenges of imaging at ULF and unique opportunities in pulse sequences, is presented. The book also presents an overview of some of the primary applications of ULF NMR/MRI being pursued.

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Genomic Medicine: Principles and Practice

by Dhavendra Kumar, Charis Eng

The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.

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OST : Clinical Medicine For The MRCP PACES Volume II (Oxford, MRCP (UK))

[FREE Download PDF] OST : Clinical Medicine For The MRCP PACES Volume II (Oxford, MRCP (UK)) Download Link(wait 5 seconds, click "skip ad" at top right, then click "Download Now" orange color button)untitled

Inborn Errors of Metabolism : From Neonatal Screening to Metabolic Pathways

Brendan Lee; Fernando Scaglia
>Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases — how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

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