PET Chemistry: The Driving Force in Molecular Imaging

cby P.A. Schubiger (Editor), L. Lehmann (Editor), M. Friebe (Editor)

ersonalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and – natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

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Pathology of the Maxillofacial Bones

Pieter Slootweg This book is divided into 3 main sections: cysts and odontogenic tumors (lesions related to the dentition); fibro-osseous lesions and giant cell lesions, which are unique to the... Read more »

Laparoscopic Urologic Surgery in Malignancies

cby Jean J.M.C.H. de la Rosette (Editor), Inderbir S. Gill (Editor)

The horizons of laparoscopic surgery are expanding, such that the overwhelming majority of abdominal urologic procedures have now been performed laparoscopically. In some of these procedures, the laparoscopic alternative has been demonstrated to be superior to its open counterpart; in others comparative analyses are ongoing; and in yet others, only the initial forays into minimally invasive surgery have been undertaken. This book sets out to collate the current body of knowledge on laparoscopic urology under one cover. The authors are respected experts in the field and have provided concise, thoughtful updates on their respective topics. The information contained in this volume will help urologists to increase their laparoscopic knowledge and skills.

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Concurrent Treatment of Ptsd and Substance Use Disorders Using Prolonged Exposure (Cope) : Patient Workbook

Sudie E. Back; Edna B. Foa; Therese K. Killeen; Katherine L. Mills
>Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE) is a cognitive-behavioral psychotherapy program designed for patients who have posttraumatic stress disorder (PTSD) and a co-occurring alcohol or drug use disorder. COPE represents an integration of two evidence-based treatments: Prolonged Exposure (PE) therapy for PTSD and Relapse Prevention for substance use disorders. COPE is an integrated treatment, meaning that both the PTSD and substance use disorder are addressed concurrently in therapy by the same clinician, and patients can experience substantial reductions in both PTSD symptoms and substance use severity. Patients use the COPE Patient Workbook while their clinician uses the Therapist Guide to deliver treatment. The program is comprised of 12 individual, 60 to 90 minute therapy sessions. The program includes several components: information about how PTSD symptoms and substance use interact with one another; information about the most common reactions to trauma; techniques to help the patient manage cravings and thoughts about using alcohol or drugs; coping skills to help the patient prevent relapse to substances; a breathing retraining relaxation exercise; and in vivo (real life) and imaginal exposures to target the patient’s PTSD symptoms.

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