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Over the past few years a remarkably rapid evolution in the professional level of neonatology and in the survival of immature infants has been witnessed. Persisting ductus arteriosus is common in this population and is associated with impaired longterm outcome. Many uncertainties exist concerning indication, approach, best time, and side effects of necessary measurements and interventions to avoid later neurodevelopmental handicaps of the survivors. Experts in neonatology and pediatric cardiology give their opinion in this book. We are sure it will help to define the level of evidence and to develop standards of intervention for persisting ductus arteriosus in Europe. Adequate dealing with the ductus will become a challenge for every perinatal center.
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Stephan Gielen; Guy De Backer; Massimo F. Piepoli; David Wood
>Covering both principles and practice, The ESC Textbook of Preventive Cardiology is a ‘state of the art’ resource for both the primary and secondary prevention of atherosclerotic cardiovascular disease. Comprehensive, practical and extensively linked to practice guidelines and recommendations from the European Association of Cardiac Prevention and Rehabilitation (EACPR), it clearly connects the latest evidence base to strategies and proposals for the implementation of prevention in clinical practice. With a strong clinical focus the topics covered range from epidemiology and risk stratification through psychological factors, behaviour and motivation to secondary prevention, integrating hospital-based and community care for cardiovascular disease prevention and information on cardio-protective drugs. Case studies, clinical decision-making trees and drug tables with recommended doses and potential side-effects make it easier than ever to implement treatments in practice. Drawing together current knowledge and evidence, and examining all aspects of preventive cardiology in one succinct volume, The ESC Textbook of Preventive Cardiology is the ideal guide for the physician and allied health professional working to prevent and treat cardiovascular disease in their daily practice.
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by Janet Medforth
Fully revised and updated to include the most up-to-date guidelines, references and resources, this new edition of the bestselling Oxford Handbook of Midwifery provides a concise and logical approach to midwifery practice in all its varied care settings. Giving a complete picture of the role of the midwife, the handbook reflects the mother’s journey through conception, pregnancy and birth to the final postnatal examination of mother and baby. This new edition includes recent advances in midwifery practice including developments in antenatal care, labour, postnatal care and infant feeding. The content is systematically structured to enable quick navigation and ensure the relevant information is at your fingertips whenever you need it. The handbook covers the vast majority of situations encountered in the many broad and varied settings of midwifery practice, from the normal, low-risk care of the mother and neonate, through to the more complex areas of working alongside obstetric or paediatric colleagues in high-risk pregnancy and birth situations. It provides all the information you will need to assist you when participating in complex care with confidence. With a wealth of references, recommendations, and guidance from the authors’ many years of experience this handbook will help you achieve the best possible results for your patients. The fundamentals of midwifery are divided into seven main sections, covering antenatal care; normal labour and birth; complicated labour and birth; postnatal care; family planning; care of the newborn; and infant feeding. It also gives information rarely covered in standard midwifery texts, including sexual health, complementary therapies, common blood values, investigations, and midwifery emergencies. Key interventions are laid out as algorithms to aid quick assimilation of the crucial facts. Written by practising midwives, and checked by subject experts, you can trust this handbook to have the late
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by Barry Halliwell, John M C Gutteridge
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss ‘in vivo’ and ‘dietary’ antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing.
This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
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