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David Schaffer; Joseph D. Bronzino; Donald R. Peterson
While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages.
The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds from biology, engineering, and the physical sciences and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.”
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Charles C. Hong; Ada S. Ao; Jijun Hao
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies
The field of regenerative medicine has advanced at a rapid pace and this comprehensive summary of new developments is a timely contribution to the field as clinical trials have begun to assess the safety and efficacy of cell-based therapies.
In “Chemical Biology in Regenerative Medicine, “an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering.
This volume provides an essential overview of this emerging technology for researchers in academic, industrial and clinical environments working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering. It is appropriate for training students and newcomers to the field, benefitting readers in broadening their knowledge and giving them insights to regenerative chemical biology, as well as encouraging readers to implement the key points in their own fields of study to develop new technologies.
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Amar Agarwal; M.D Dhivya Ashok Kumar
Written by the leading authorities in the field, Essentials of OCT in Ocular Disease is a core clinical reference on this important new technology used to examine the structure of the eye. It provides residents and practicing ophthalmologists with essential information on how to use OCT in various clinical scenarios and guidance on patient management. Chapters include coverage of recent innovative diagnostic applications as well
as OCT-guided surgical procedures,including IOL position, DMEK, PDEK, GLUED IOL, and subtenon injection.
Key Features:Edited by Amar Agarwal, a pioneer in OCT research, with chapters written by world-renowned experts in the use of OCT, including Jay Duker, Roger Steinert, and Carol Shields Covers both anterior and posterior applications of OCT and recent modifications in OCT systems Online access to videosdemonstrating OCT-guided surgical procedures
This book is an indispensable clinical guide for residents and fellows in ophthalmology as well as an excellent desk reference for practicing ophthalmologists — it will be a treasured and clinically useful volume in their medical libraries throughout their careers.
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Alan R. Cohen
Pediatric neurosurgery is a uniquely exacting subspecialty in which surgeons are given the extraordinary privilege of alleviating suffering for gravely ill children, and in best-case scenarios, restoring their health. Understanding the vast and complex anatomy, pathology, and pathophysiology that evolves throughout childhood presents considerable challenges. Further, the field is rapidly progressing with advancements in neurodiagnostic imaging and surgical instrumentation, as well as an expanding knowledge of the molecular and genetic bases underlying many neurosurgical disorders.
While this book’s primary focus is on how to achieve technical excellence in the OR, this is a remarkably personal book about the art of pediatric neurosurgery. In it you will find wisdom gained from decades of experience. Read this book, use the knowledge you gain from it, and you will become a safer, more skillful neurosurgeon.
Special Features:More than 800 stunning, full-color illustrations Online access to videos in which experts from all over the world demonstrate the operative nuances and techniques that help surgeons get patients safely in and out of the OR Written by master surgeons from 10 countries who share a wealth of insightful wisdom garnered from years of experience, refinement of surgical techniques, and development of numerous innovations Surgical pearls, operative nuances, procedural modifications, and techniques for avoiding and dealing with pitfalls
This state-of-the-art volume is an unparalleled teaching tool that reveals invaluable tricks of the trade. It is an essential resource for pediatric and general neurosurgeons, neurosurgery residents and fellows.